A case of 53-year-old man with the diagnosis of angioimmunoblastic
lymphadenopathy(AILD) is reported.
This case represents a deficiency of the T-cell regulatory functions probably
predisposing a nonneoplastic proliferation of the B-cell system with immunoblastic
transformation of many lymphocytes an6 excessive production of immunoglobulins, which
had an acute onset with generalized lymphadenopathy, high-grade fever, weight loss,
hepatosplenomegaly, skin rash with pruritus, and malaise.
Various laboratory studies showed polyclonal hypergammaglobulinemia, anemia with
positive Coombs' test, leukocytosis with relative eosinophilia and lymphocytopenia.
Serum immunoglobulins (IgG and IgM) were increase4 but IgA and complement(C3)
were within normal level. Blood T-lymphocytes were markedly decreased in number.
Histopathologic findings of lymph node prior to therapy were characterized by a)
proliferation of immunoblasts, plasmacytoid immunoblasts, plasma cells and lymphocytes,
b) prominent proliferation of arborizing small vessels and c) deposit of PAS-positive
amorphous material in the interstitium.
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